Intracranial electroencephalography features of young and old mice under midazolam administration

This study aimed to monitor the intracranial electroencephalography (in the cortex and hippocampus) in free-moving young and old mice under midazolam administration. Behavioral assessment revealed that compared with young mice, old mice had a longer immobility time with a similar midazolam dose. In both young and old mice, midazolam significantly suppressed the total, δ (0.5–4 Hz), θ (4–8 Hz), and α (8–12 Hz) power, and thus induced an increase in the relative β (12–30 Hz) and γ (30–140 Hz) power. Age had a main effect on the γ frequency; specifically, under normal conditions, old mice had a lower γ power than young mice. After midazolam administration, the relative power of high γ frequency (50–140 Hz) remained lower in old mice than in young mice. Our findings suggest that a lower γ power is indicative of an aging brain.
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research