Sertoli-Leydig cell tumor of ovary in children: A report of two cases, including retiform variant

Indian J Pathol Microbiol. 2021 Jul-Sep;64(3):559-562. doi: 10.4103/IJPM.IJPM_443_20.ABSTRACTSertoli-Leydig cell tumors (SLCTs) are rare and heterogeneous group of ovarian neoplasms which belong to the sex cord-stromal category of tumors. SLCTs are classified into well, intermediate, and poorly differentiated types. Retiform growth pattern and heterologous elements are commonly found in moderately and poorly differentiated tumors. SLCTs are usually encountered in the third decade of life and patients most often present with virilization. Here, we report two cases of SLCTs of the ovary, both in 2-year-old girls without any hormonal symptoms. The first case was a retiform variant of Sertoli-Leydig cell tumor and the second was a well-differentiated SLCT. Because of its wide spectrum of morphology, several tumors enter in the differential diagnosis and the presence of heterologous elements further complicates the diagnosis. Here, we have described the morphological characteristics of these tumors and discussed their differential diagnoses. SF-1, WT1, and α-inhibin are useful immunostains in establishing the diagnosis and differentiating these from the more the common ovarian germ cell tumors in children.PMID:34341273 | DOI:10.4103/IJPM.IJPM_443_20
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Source Type: research