Serum 25(OH)D Concentration and Cardiovascular Disease Risk Markers Among Middle-Aged Healthy and Type 2 Diabetic Subjects
Horm Metab Res DOI: 10.1055/a-1534-2747Vitamin D deficiency is a major widespread health concern and is linked to a high
risk of cardiovascular disease (CVD). Thus, we have investigated the association
of vitamin D with various CVD risk markers. The present study comprises 90
control and 90 type 2 diabetes mellitus (T2DM) subjects of both sexes (age
range, 30–50 years). The 25 hydroxyvitamin D [25(OH)D] and CVD risk
markers including high sensitive C-reactive protein (hs-CRP), monocyte
chemoattractant protein-1 (MCP-1), intact parathyroid hormone (I-PTH),
fibroblast growth factor (FGF)-23, erythrocyte sedimentation rate (ESR), and
fibrinogen were measured by using standard assays. Blood viscosity and
atherogenic index of plasma calculated using standard formulae. The ten-year
cardiovascular risk was assessed using the Framingham risk score (FRS). 25(OH)D,
hs-CRP, MCP-1, FGF-23, ESR, fibrinogen, atherogenic index of plasma and FRS were
significantly different between control and T2DM groups (p<0.05).
25(OH)D showed a significant negative correlation with MCP-1, ESR, blood
viscosity, atherogenic index of plasma and FRS among total study subjects.
Further, logistics regression analysis showed an association of 25(OH)D with
MCP-1, hematocrit, fibrinogen, and blood viscosity. The association between
25(OH)D a...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Dhas, Yogita Banerjee, Joyita Damle, Gauri Mishra, Neetu Tags: Endocrine Care Source Type: research
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