Myasthenia Gravis Lambert-Eaton overlap syndrome induced by nivolumab in a metastatic melanoma patient

ConclusionWe describe the first case of MG-LE overlap syndrome diagnosed after anti-PD1 immunotherapy for metastatic  melanoma, which appeared after radiation therapy and then relapsed after brain radiation necrosis. We hypothesized a role for brain inflammation as a trigger for MG-LE onset. Neuro-muscular junctions disease induced or revealed by checkpoint inhibitors can be challenging and requires long-term f ollow-up.
Source: Neurological Sciences - Category: Neurology Source Type: research