Exhaled breath biomarkers of influenza infection and influenza vaccination
Respiratory viral infections are considered a major public health threat, and breath metabolomics
can provide new ways to detect and understand how specific viruses affect the human pulmonary
system. In this pilot study, we characterized the metabolic composition of human breath for an early
diagnosis and differentiation of influenza viral infection, as well as other types of upper
respiratory viral infections. We first studied the non-specific effects of planned seasonal
influenza vaccines on breath metabolites in healthy subjects after receiving the immunization. We
then investigated changes in breath content from hospitalized patients with flu-like symptoms and
confirmed upper respiratory viral infection. The exhaled breath was sampled using a custom-made
breath condenser, and exhaled breath condensate (EBC) samples were analysed using liquid
chromatography coupled to quadruplole-time-of-flight mass spectrometer (LC-qTOF). All metabolomic
data was analysed using both targeted...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Eva Borras, Mitchell M McCartney, Cai H Thompson, Robert J Meagher, Nicholas J Kenyon, Michael Schivo and Cristina E Davis Source Type: research
More News: Influenza | Influenza Vaccine | International Medicine & Public Health | Respiratory Medicine | Study | Vaccines