Pathological and molecular diagnosis of concurrent canine babesiosis and pyometra in a Belgian Malandis bitch

AbstractVarious authors have performed microscopic and molecular diagnosis and pathological evaluations of babesiosis as well as the clinical, bacteriological, and uterine histopathological investigations  of pyometra separately in dogs. However, the present report investigated a case of concurrent canine babesiosis and pyometra in a dog with particular emphasis on histopathological evaluations associated with multi-organ failure and death arising from both conditions. The collection of appropriate samples for ante-mortem hematological and microbial evaluations, including post-mortem molecular diagnosis and histopathological investigations, based on standard procedures, followed clinical examination of the Belgian Malandis bitch. Neutrophilia, lymphocytosis, monocytosis, and eosinophilia char acterized the observed leukocytosis. Vaginal discharge cytology revealed degenerated neutrophils and epithelial cells with some rods while the culture yieldedEscherichia coli andCandida albicans growths. Although the microscopic examination of the thin blood smear did not reveal the presence ofBabesia organisms, molecular analysis of the heart blood revealed the presence ofBabesia  vogeli. Visible organ enlargement and fluid effusions with other signs of vascular compromise occurred, evidenced microscopically by congestion, hemorrhage, edema, and mononuclear cellular infiltration of affected organs. Lesions indicated vascular dysfunction with marked systemic inflammatory responses res...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research