Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

In this study, 85 patients with t(8;21) AML were enrolled. The mRNA expression levels of CD34+CD117dim-associated genes (LGALS1, EMP3, andCRIP1) and CD34+CD117bri-associated genes (TRH, PLAC8, andIGLL1) were measured using quantitative reverse transcription PCR. Associations between gene expression and clinical outcomes were determined using Cox regression models. Results showed that patients with highLGALS1, EMP3, orCRIP1 expression had significantly inferior overall survival (OS), whereas those with highTRH orPLAC8 expression showed relatively favorable prognosis. Univariate analysis revealed that CD19, CD34+CD117dim proportion,KIT mutation, minimal residual disease (MRD), and expression levels ofLGALS1, EMP3, CRIP1, TRH andPLAC8 were associated with OS. Multivariate analysis indicated thatKIT mutation, MRD andCRIP1 andTRH expression levels were independent prognostic variables for OS. Identifying the clinical relevance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML.
Source: Frontiers of Medicine - Category: General Medicine Source Type: research