P –108 Which infertile men with normal semen analysis deserve a second semen analysis in the real-life setting?

AbstractStudy questionGuidelines suggest that one semen analysis is sufficient during the diagnostic work-up of an infertile man in the case of normality as for WHO criteria.Summary answerWe investigated the rate and the clinical features of men with abnormal sperm parameters at a second test, after a normal first semen analysis.What is known alreadyA second test is recommended when the first semen analysis depicted abnormal sperm parameters.Study design, size, durationComplete demographic, clinical and laboratory data from 1358 consecutive primary infertile men (infertility as for WHO definition) were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Serum hormones were measured in every patient. Patients underwent two consecutive semen analyses at the same laboratory, which followed 2010 WHO reference criteria.Participants/materials, setting, methodsDescriptive statistics and logistic regression models tested the association between clinical variables and semen parameters. Receiver operative characteristic (ROC) curves were used to assess the relationship between clinical variables and to create a composite risk score for pathological sperm parameters at a second test.Main results and the role of chanceAt first analysis, 212 (15.6%) infertile men had normal semen parameters. Of 212, 87 (41.0%) had a second normal semen analysis, while 80 (37.7%), 35 (16.5%) and 10 (4.7%) men showed 1, 2 and 3 pathological sperm parameters at s...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research