P –085 Sperm retrieval after microdissection testicular sperm extraction (micro-TESE) and pregnancy outcomes of intracytoplasmic sperm injection (ICSI) in men with Klinefelter syndrome

AbstractStudy questionWhat are the sperm retrieval rate and ICSI outcomes in azoospermic men with Klinefelter syndrome (KS)?Summary answerIn men with KS, a sperm retrieval rate of 51.3% after the first attempt micro-TESE, and 4 live births after ICSI were observed. What is known already: Klinefelter syndrome (KS) is encountered in 10% of men with azoospermia. Micro-TESE is presently used to treat infertility for KS patients with nonobstructive azoospermia. The retrieved sperms can be used for ICSI. Study design, size, duration: From June 2019 to July 2020, 39 azoospermic patients with KS were examined for the presence of testicular spermatozoa. Participants/materials, setting, methods: Participants were recruited from couples attending the Andrology and Fertility Hospital of Hanoi Vietnam, for infertility treatment. Micro-TESE was performed to extract testicular tissue. After retrieval, ICSI was used with fresh sperm. Main results and the role of chance: The sperm retrieval rate of first attempt micro-TESE in KS men was 51.3% (20/39). Logistic regression analysis showed patient age did not affect the sperm retrieval rate of micro-TESE (OR 0.99, 95% CI 0.88 - 1.11). Similarly, no association was observed between serum FSH, LH, testosterone level, and testicular volume with the success of sperm retrieval. The fertilization rate after ISCI in patients with retrieved sperm was 60% (12/20). Clinical pregnancy and ongoing pregnancy rates were 50% (10/20) and 40% (8/20). There were ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research