O-233 Micronized progesterone plus dydrogesterone versus micronized progesterone alone for luteal phase support in frozen-thawed cycles: a prospective cohort study

AbstractStudy questionDoes the addition of oral dydrogesterone to vaginal progesterone as luteal phase support improve pregnancy outcomes during frozen embryo transfer (FET) cycles compared with vaginal progesterone alone?Summary answerLuteal phase support with oral dydrogesterone added to vaginal progesterone improves live birth rates and reduces miscarriage rates compared with vaginal progesterone alone.What is known alreadyProgesterone is an important hormone that triggers secretory transformation of the endometrium to allow implantation of the embryo. During in vitro fertilization (IVF), exogenous progesterone is administered for luteal phase support. However, there is wide inter-individual variation in absorption of progesterone via the vaginal wall. Oral dydrogesterone is effective and well tolerated when used to provide luteal phase support after fresh embryo transfer. However, there are currently no data on the effectiveness of luteal phase support with the combination of dydrogesterone with vaginal micronized progesterone compared with vaginal micronized progesterone after FET.Study design, size, durationProspective cohort study conducted at an academic infertility center in Vietnam from 26 June 2019 to 30 March 2020.Participants/materials, setting, methodsWe studied 1364 women undergoing IVF with FET. The luteal support regimen was either vaginal micronized progesterone 400  mg twice daily plus oral dydrogesterone 10 mg twice daily (second part of the study) or ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research