P –406 Placental histopathology is different in specific subsets of ICSI singleton pregnancies with programmed cycles : a prospective study

AbstractStudy questionDoes embryo vitrification or donor oocytes (DO) alter the histopathology of the placenta in ICSI singleton pregnancies with similar endometrial preparation?Summary answerPlacentas from programmed cycles had significantly more immune/idiopathic-inflammation with vitrified-thawed embryos versus fresh transfer and significantly more maternal vascular-malperfusion(MVM) in DO versus autologous oocyte(AO) pregnancies.What is known alreadyDO pregnancies and frozen embryo transfer(FET) pregnancies with programmed cycles are associated with hypertensive complications. As these complications are linked with abnormal placentation, comparing the placental histopathology in these pregnancies may point to a causative association.Studies of placental histopathology in DO in comparison to AO pregnancies show a dysregulated immune process and vasculopathy. The hormonal milieu during implantation remains an important confounder.Placental histopathology in fresh/ frozen cycles has recently shown variable results. To isolate the effect of embryo vitrification on placental histopathology, the donor oocyte model can provide valuable data, which till now is scarcely available.Study design, size, durationA prospective cohort study conducted in a tertiary center from 2018 –2020.Placental histopathology, pregnancy-outcomes were studied in 116 ICSI singleton pregnancies≥28 weeks.Group1-Pregnancies with DO, by FET(n = 32) and freshET(n = 34) were compared to study the e...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research