Study of the Antimalarial Activity of the Leaf Extracts and Fractions of < em > Persea americana < /em > and < em > Dacryodes edulis < /em > and Their HPLC Analysis

Evid Based Complement Alternat Med. 2021 Jul 17;2021:5218294. doi: 10.1155/2021/5218294. eCollection 2021.ABSTRACTIn the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant (p < 0.05) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.PMID:34335810 | PMC:PMC8313334 | DOI:10.1155/2021/5218294

Source: Evidence-based Complementary and Alternative Medicine - August 2, 2021 Category: Complementary Medicine Authors: Philip F Uzor Chukwuebuka K Onyishi Adaeze P Omaliko Somtochukwu A Nworgu Onyemaechi H Ugwu Ngozi J Nwodo Source Type: research