Contribution of reactive oxygen species to CAA [Neuroscience]

Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid β peptide (Aβ) within walls of cerebral arteries and is an important cause of intracerebral hemorrhage, ischemic stroke, and cognitive dysfunction in elderly patients with and without Alzheimer’s Disease (AD). NADPH oxidase-derived oxidative stress plays a key role in soluble...

Source: Proceedings of the National Academy of Sciences - February 24, 2015 Category: Science Authors: Han, B. H., Zhou, M.-l., Johnson, A. W., Singh, I., Liao, F., Vellimana, A. K., Nelson, J. W., Milner, E., Cirrito, J. R., Basak, J., Yoo, M., Dietrich, H. H., Holtzman, D. M., Zipfel, G. J. Tags: PNAS Plus Source Type: research