Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations

Expert Rev Clin Pharmacol. 2021 Jul 27. doi: 10.1080/17512433.2021.1961578. Online ahead of print.ABSTRACTINTRODUCTION: : Severe infections continue to impose a major burden on critically ill children and mortality rates remain stagnant. Outcomes rely on accurate and timely delivery of antimicrobials achieving target concentrations in infected tissue. Yet, developmental aspects, disease-related variables, and host factors may severely alter antimicrobial pharmacokinetics in pediatrics. The emergence of antimicrobial resistance increases the need for improved treatment approaches.AREAS COVERED: : This narrative review explores why optimization of antimicrobial therapy in neonates, infants, children and adolescents is crucial and summarizes the possible dosing approaches to achieve antimicrobial individualization. Finally, we outline a roadmap towards scientific evidence informing the development and implementation of precision antimicrobial dosing in critically ill children.The literature search was conducted on PubMed using the following key words: neonate, infant, child, adolescent, pediatrics, antimicrobial, pharmacokinetic, pharmacodynamic target, Bayes dosing software, optimizing, individualizing, personalizing, precision dosing, drug monitoring, validation, attainment, software implementation. Further articles were sought from the references of the above searched articles.EXPERT OPINION: : Recently, technological innovations have emerged that enabled the development of i...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research