Heterologous Immunological Effects of Early BCG Vaccination in Low-Birth-Weight Infants in Guinea-Bissau: A Randomized-controlled Trial

Conclusion. Four weeks after immunization, BCG-vaccinated infants have a significantly increased production of cytokines upon heterologous challenge, particularly T helper cell type 1 polarizing and typically monocyte-derived pro-inflammatory cytokines. BCG may accelerate the development of the neonatal immune system, mediating comprehensive protection against infections and mortality.

Source: The Journal of Infectious Diseases - February 23, 2015 Category: Infectious Diseases Authors: Jensen, K. J., Larsen, N., Biering-Sorensen, S., Andersen, A., Eriksen, H. B., Monteiro, I., Hougaard, D., Aaby, P., Netea, M. G., Flanagan, K. L., Benn, C. S. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research