New Series of Imidazoles Showed Promising Growth Inhibitory and Curative Potential Against Trypanosoma Infection

In conclusion, this is the first study demonstrating the potential of these new series of imidazoles to clear the systemic parasite burden in infected rats. Furthermore, a high selectivity index of imidazoles towards T. congolense in vitro and the oral LD50 in rats support anti-parasite specific action. Together, findings support the anti-parasitic prospects of the new series of imidazole derivatives.PMID:34211341 | PMC:PMC8223535

Source: The Yale Journal of Biology and Medicine - July 2, 2021 Category: Universities & Medical Training Authors: Oluyomi Stephen Adeyemi Nthatisi Innocentia Molefe-Nyembe Abiodun Omokehinde Eseola Winfried Plass Oluwatosin Kudirat Shittu Ibrahim Olatunji Yunusa Olubunmi Atolani Ikponmwosa Owen Evbuomwan Oluwakemi J Awakan Keisuke Suganuma Kentaro Kato Source Type: research