Schiff bases of sulphonamides as a new class of antifungal agent against multidrug ‐resistant Candida auris

We report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against allCandida species tested including multidrug-resistantC.  auris. The drug-like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed toward pre-clinical evaluation. AbstractInvasiveCandida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in severalCandida species that cause Candidemia, includingC.  glabrata andC.  auris, with limited numbers of antifungal agents available to treat patients with invasive Candida infections. Therefore, there is an urgent need to discover new antifungal agents that work against multidrug-resistantCandida species, particularlyC.  auris, which has been identified as an emerging global pathogen. In this article, we report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against allCandida species tested, with an MIC range of 4 –32 µg/ml. Compound2b showed activity againstC.  glabrata and a panel of fluconazole-resistantC.  auris strains, with MICs of 4 –16 µg/ml. The drug-like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed tow...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research