Thermodynamic profile of mutual subunit control in a heteromeric receptor [Biophysics and Computational Biology]

Cyclic nucleotide-gated (CNG) ion channels of olfactory neurons are tetrameric membrane receptors that are composed of two A2 subunits, one A4 subunit, and one B1b subunit. Each subunit carries a cyclic nucleotide-binding domain in the carboxyl terminus, and the channels are activated by the binding of cyclic nucleotides. The mechanism...

http://www.pnas.org/content/118/30/e2100469118.short?rss=1

Source: Proceedings of the National Academy of Sciences - July 23, 2021 Category: Science Authors: Jana Schirmeyer, Sabine Hummert, Thomas Eick, Eckhard Schulz, Tina Schwabe, Gunter Ehrlich, Taulant Kukaȷ, Melanie Wiegand, Christian Sattler, Ralf Schmauder, Thomas Zimmer, Nisa Kosmalla, Jan Munch, Michele Bonus, Holger Gohlke, Klaus Benndorf Tags: Biophysics and Computational Biology, Physiology Biological Sciences Source Type: research