Genes, Vol. 12, Pages 1115: DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome
Genes, Vol. 12, Pages 1115: DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome
Genes doi: 10.3390/genes12081115
Authors:
Oxana Yu. Naumova
Rebecca Lipschutz
Sergey Yu. Rychkov
Olga V. Zhukova
Elena L. Grigorenko
Recent research has provided evidence on genome-wide alterations in DNA methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with Down syndrome (DS) across different developmental stages. Here, we report new data on the systematic genome-wide DNA methylation perturbations in blood cells of individuals with DS from a previously understudied age group—young children. We show that the study findings are highly consistent with those from the prior literature. In addition, utilizing relevant published data from two other developmental stages, neonatal and adult, we track a quasi-longitudinal trend in the DS-associated DNA methylation patterns as a systematic epigenomic destabilization with age.
Source: Genes - Category: Genetics & Stem Cells Authors: Oxana Yu. Naumova Rebecca Lipschutz Sergey Yu. Rychkov Olga V. Zhukova Elena L. Grigorenko Tags: Article Source Type: research
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