miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8

Conclusion
Our data reveal a role of miR-21-3p in regulating HDAC8 expression and Akt/Gsk3β pathway, and suggest that modulation of miR-21-3p levels may provide a therapeutic approach for cardiac hypertrophy.

Source: Cardiovascular Research - February 23, 2015 Category: Cardiology Authors: Yan, M., Chen, C., Gong, W., Yin, Z., Zhou, L., Chaugai, S., Wang, D. W. Tags: Cardiac biology and remodelling Source Type: research