Emergence of Orai3 activity during cardiac hypertrophy

Conclusion
Cardiac Orai3 is the essential partner of STIM1 and drives voltage-independent Ca2+ entries in adult cardiomyocytes. Arachidonic acid-activated currents, which are supported by Orai3, are present in adult cardiomyocytes and increased during hypertrophy.

Source: Cardiovascular Research - February 23, 2015 Category: Cardiology Authors: Saliba, Y., Keck, M., Marchand, A., Atassi, F., Ouille, A., Cazorla, O., Trebak, M., Pavoine, C., Lacampagne, A., Hulot, J.-S., Fares, N., Fauconnier, J., Lompre, A.-M. Tags: Cardiac biology and remodelling Source Type: research