CCR5- Δ32 polymorphism: a possible protective factor for post-stroke depressive symptoms

CONCLUSION: Carriers of the CCR5-Δ32 allele had a lower tendency to develop depressive symptoms post-stroke, and this phenomenon was more prominent in women. These findings could have clinical implications; they suggest a mechanism-based treatment target for post-stroke depression. Drugs mimicking this loss-of-function mutation exist and could serve as a novel antidepressant therapy.PMID:34291627 | DOI:10.1503/jpn.200197

Source: Journal of Psychiatry and Neuroscience - July 22, 2021 Category: Psychiatry Authors: Oren Tene Hen Hallevi Jeremy Molad Saly Usher Estelle Seyman Natan M Bornstein Shani Shenhar-Tsarfaty Einor Ben Assayag Source Type: research