Non-alcoholic fatty liver disease: New potential protection against the condition

FATTY liver disease is an umbrella term for conditions involving a fatty build-up in the liver. Although non-alcoholic liver disease can be treated when detected in the early stages, late-stage NAFLD can cause serious damage to the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Contributors : Xuezhu Li ; Dipankar Bhattacharya ; Scott L Friedman ; John C HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) that underlies a growing prevalence of cirrhosis and liver cancer worldwide. Clinical studies suggest that NASH is an independent risk factor for chronic kidney disease (CKD), but models and mechanisms linking these two diseases are lacking. Here, we have characterized the renal function, histological features, and transcriptomic profile in a well-validated murin...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
AbstractReflecting the growing interest in early diagnosis of non-alcoholic fatty liver disease in recent years, the development of noninvasive and reliable fat quantification methods is needed. Dual-energy computed tomography (DE-CT) is a quantitative diagnostic imaging method that estimates the composition of the imaging target using a material decomposition technique based on the X-ray absorption characteristics peculiar to substances from DE-CT scanning using X-rays generated with different energies (tube voltage). In this review article, we first explain the basic principles and technical aspects of DE-CT. Then, we wi...
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
AbstractIntroductionNon-alcoholic fatty liver disease (NAFLD) is a metabolic condition that comprises a spectrum of liver diseases. Non-pharmacological treatments such as functional food consumption and aerobic exercise training (AET) have been recommended.ObjectiveTo evaluate the combined effects of a çai pulp consumption and AET on the development of NAFLD induced by a high-fat diet.MethodsMale Fischer rats received either standard or high-fat diet. Animals (21.8% lard and 1% cholesterol) were treated with lyophilized a çai pulp (1%), AET or açai plus AET for 8 weeks. Exercise capacity, body fat...
Source: Sport Sciences for Health - Category: Sports Medicine Source Type: research
AbstractObjectivesTo evaluate the diagnostic performance of liver surface nodularity (LSN) for the assessment of advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).MethodsWe retrospectively analysed patients with pathologically proven NAFLD who underwent liver MRI. Demographic, clinical, and laboratory data (including FIB-4 scores) were gathered. The SAF score was used to assess NAFLD. MRI-proton density fat fraction (PDFF) and LSN were determined on pre-contrast MR sequences. ROC curve analysis was performed to evaluate the diagnostic performance of MRI-LSN for the diagnosis of advanced (F3-F4) l...
Source: European Radiology - Category: Radiology Source Type: research
CONCLUSION: Polyphenols are relevant bioactive compounds in terms of prevention and treatment of NAFLD, which exhibit low bioavailability and instability in biological systems that could limit their health effects. These drawbacks reinforce the necessity of further studies to improve the efficacy of polyphenol formulations for human interventions.PMID:34525916 | DOI:10.2174/0929867328666210825111350
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Animal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease treatment based on alternative models in a fast, safe, and economic manner is an important, yet challenging goal. In this paradigm, the fruit-fly Drosophila melanogaster has become a powerful model for biomedical research, considering its short life cycle and low-cost maintenance. In addition, biological processes are conserved and homologs of ∼75% of human disease-related genes are found in the fruit-fly. Therefore, this model has been used in innovative approac...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In conclusion, adapted methods of fixation applied to human liver tissue revealed that single, huge fat droplets cause necrosis and inflammation in single parenchymal cells. Fat dropl ets also collect Mallory substance and give rise to sinusoidal fat emboli. Therefore, degreasing of the liver seems to be an essential therapeutic first step in the self-repairing of non-alcoholic fatty liver disease. This might directly reduce single-cell steatotic necrosis and inflammation as elem ents in non-alcoholic steatohepatitis progression.
Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
ConclusionsThe frequency of NAFLD was high in our patient group. Significant NAFLD-presence factors were high BMI, low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level. A further study is warranted to determine the effects of the NAFLD-presence factors on stroke onset or prevention.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
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