Chronic Kidney Disease Rescuing kidney patients from early demise: Role of anti-cytokine therapies
Biomarkers of the inflammatory state are elevated in individuals with chronic kidney disease (CKD) and are also robust predictors of cardiovascular disease (CVD) and mortality in this population. In addition to its predictive ability, inflammation has been implicated in the pathogenesis of atherosclerotic CVD, primarily through NLRP3 inflammasome and interleukin-1 (IL-1) and interleukin-6 (IL-6) signaling pathways 1. Based on these data, it has been suggested that ameliorating the inflammatory response through anti-cytokine therapies could improve CVD risk factors and potentially survival in CKD.
Source: Kidney International - Category: Urology & Nephrology Authors: T. Alp Ikizler, Jonathan Himmelfarb Tags: nephrology digest Source Type: research