Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin in Hypertensive Diabetic Patients with Nephropathy: A Randomized Trial
Horm Metab Res 2021; 53: 470-477 DOI: 10.1055/a-1517-6643Angiogenesis is a multistep process implicated in the pathophysiology and
progression of diabetic nephropathy (DN). Angiotensin-converting enzyme
inhibitors (ACEI) and calcium channel blockers (CCB) have an important role in
DN. We performed a randomized-controlled trial of lisinopril alone (an ACEI) or
in combination with verapamil (a CCB) as a therapy for DN in type 2 diabetes
mellitus (T2DM) patients with hypertension (HTN) and urinary albumin creatinine
ratio (UACR) (30â300âmg/g) also to evaluate their effect
on UACR, the angiogenic proteins: Angiopoietin 2 (Ang-2) and Endostatin (EST).
Forty T2DM patients with microalbuminuria, aged 45â65 years were
included. Patients were randomly assigned into group 1 receiving oral lisinopril
and group 2 receiving oral lisinopril and verapamil once daily. After 3 months
follow-up fasting blood glucose (FPG), HbA1c, lipid profile, UACR, serum urea
and creatinine levels were assessed. EST and Ang-2 were measured using ELISA
technique. Baseline Ang-2 and EST levels were elevated in both groups compared
with controls (p<0.001). After follow-up, group 2 had significantly
decreased FPG, HbA1c, UACR, EST and Ang-2 compared with their baseline levels
(p<0.001 for all comparisons) and with group 1 (p<0.001). No
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Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Salem, Mohamed Sallam, Al-Aliaa M. Abdel-Aleem, Eman El-Mesallamy, Hala O. Tags: Endocrine Care Source Type: research
More News: Calcium | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Hormones | Hypertension | Lisinopril | Urology & Nephrology | Verapamil