Advantages of interstitial radioactive seed implantation for the treatment of Stage III pancreatic cancer
Conclusions: Radioactive seed implantation obviously advantageous for the treatment of Stage III pancreatic cancer.
A new study finds that cases of pancreatic cancer increased among both men and women between 2000 and 2018, particularly among women 15 to 34 years of age, and it's not clear why.Reuters Health Information
Early research suggests one-stop radiotherapy after surgery may"improve local control of pancreatic cancer."Medscape Medical News
Condition: Pancreatic Cancer Interventions: Drug: Pembrolizumab; Drug: Olaparib Sponsors: Cambridge University Hospitals NHS Foundation Trust; National Institute for Health Research, United Kingdom Not yet recruiting
British Journal of Cancer, Published online: 26 October 2021; doi:10.1038/s41416-021-01580-xA risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO
Effective in situ cancer vaccines require both a means of tumor cell death and a source of adjuvant to activate local dendritic cells. Studies have shown that the use of radiotherapy (RT) to induce tumor cell death and anti-CD40 to activate dendritic cells can result in in situ vaccination in animal models. Here, investigations are carried out on potential strategies to enhance such in situ vaccination. Strategies investigated include the use of smart immunogenic biomaterials (IBM) loaded with anti-CD40 in different tumor types including immunologically cold tumors like pancreatic and prostate tumors. The use of downstream...
Conclusion: Modulating B cell development, neoangiogenesis and fibrosis, and SDF-1/CXCL12 may play a role in IgG4-RD. The higher levels observed in IgG4-RD, as compared to SSj, which closely mimics the disease, can be related to a different pattern of lesions, with prevalent fibrosis seen in IgG4-RD. Taken together, these findings suggest that drugs acting on the CXCL12/CXCR4/CXCR7 axis may affect IgG4-RD.
In this study, the ability of circRNA circ_0092367 to enhance gemcitabine efficacy was tested and the underlying molecular mechanism of circ_0092367 was investigated. The expression levels of circ_0092367, miR-1206, and ESRP1 were measured using qRT-PCR experiments. The effects of circ_0092367, miR-1206, and ESRP1 on PC cell lines exposed to gemcitabine were examined by CCK-8 assays. We performed luciferase assays to determine the relationship between circ_0092367 and miR-1206 and between miR-1206 and ESRP1. We demonstrated that circ_0092367 was significantly downregulated in PC tissues and cell lines, and a high expressio...
Experimental &Molecular Medicine, Published online: 26 October 2021; doi:10.1038/s12276-021-00687-8Boosting the activity of a tumor suppressor pathway in pancreatic cancer may reduce the risk of metastasis. Reduced expression of a tumor suppressor gene called Krüppel-like factor 10 (KLF10) is found in breast, lung and pancreatic cancers. KLF10 deficiency in pancreatic cancer is linked to accelerated cancer progression and metastasis, but the underlying mechanisms are unclear. In experiments on mouse models and human cell cultures, Hui-Ju Ch’ang at the National Institute of Cancer Research in Zhunan, Taiwan, ...
PANCREATIC cancer develops when cancerous cells in the pancreas - an organ in the top part of your tummy - divide and multiply uncontrollably. One telltale sign of this process can surface immediately after having a poo.