Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 Signalling pathway

Hepatic gluconeogenesis plays a crucial role in maintaining blood glucose homeostasis in mammals. Globe knockout of suppressor of cytokine signalling-2 (SOCS2), a feedback inhibitor of cytokine signalling, has been shown resistant to high-fat-diet (HFD)-induced hepatic steatosis with impaired glucose tolerance in mice. However, the underlying mechanism of SOCS2 regulates hepatic glucose homeostasis still undefined. In the present study, we demonstrated that the hepatic SOCS2 expression is markedly reduced in fasted C57BL/6  J mice or db/db mice.

Source: Metabolism - Clinical and Experimental - June 28, 2021 Category: Biomedical Science Authors: Xu ZHANG, Yuan ZHUANG, Tian QIN, Meijia CHANG, J.I. Xuetao, Ning WANG, Zhilei ZHANG, Hongwen ZHOU, Qian WANG, L.I. John Zhong Source Type: research