Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging

Conclusions: Our findings establish a pathogenic role for increased Phe levels in cardiac aging, linking plasma Phe levels to cardiac senescence via dysregulated Phe catabolism along a hepatic-cardiac axis. They highlight Phe/PAH modulation as a potential therapeutic strategy for age-associated cardiac impairment.PMID:34162223 | DOI:10.1161/CIRCULATIONAHA.121.054204

Source: Circulation - June 24, 2021 Category: Cardiology Authors: Gabor Czibik Zaineb Mezdari Dogus Murat Altintas Juliette Br éhat Maria Pini Thomas d'Humi ères Tha ïs Delmont Costin Radu Marielle Breau Hao Liang Cecile Martel Azania Abatan Rizwan Sarwar Oph élie Marion Suzain Naushad Yanyan Zhang Maissa Halfaoui N Source Type: research