Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1 β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes

Conclusion: Exosomal PCGEM1 from OA-FLSs facilitated IL-1β-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR-142-5p and upregulating RUNX2, which offered new insights into the pathogenesis of OA.PMID:34160339 | DOI:10.1080/08820139.2021.1936010
Source: Immunological Investigations - Category: Allergy & Immunology Authors: Source Type: research