A Mini Review on the Effectiveness of Peptoids as Therapeutic Interventions against Neurodegenerative Diseases

Curr Protein Pept Sci. 2021 Jun 15. doi: 10.2174/1389203722666210615125852. Online ahead of print.ABSTRACTNeurodegenerative diseases emerged as one of the major age-associated diseases in the recent years. Hence, the urge for understanding the mechanism and to find targeted therapeutics becomes inevitable. Peptide-based compounds emerged as one of the important tools for its therapy. But due to a lack of tolerability, specificity and proteolytic degradation, it loses its applicability in a wider sense. Thus, the search for suitable alternatives or peptidomimetics becomes an important criterion for neurotherapeutics. One of the versatile peptidomimetics are N-substituted glycines or Peptoids, which retain many properties of peptides but are successful in evading the drawbacks of peptides. Peptoids are manifested with greater cellular permeability, less immunogenicity and their ability to be administered intra-nasally. These properties enhance their potential as neurotherapeutics with respect to their peptide counterpart. Recently, peptoids have been explored towards neurotherapeutic applications as aggregation inhibitors, cell signaling pathways modulator, and as agents for inhibiting inflammations via multiple mechanisms. Peptoids, due to their versatility and low production cost, are becoming popular among peptidomimetics as potential neurotherapeutic agents. In this review, the diverse applications of peptoids with respect to neurodegenerative disease have been explored.PMI...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Source Type: research