A promising new target for urinary tract infections and kidney stones
(Tokyo Medical and Dental University) Researchers from Tokyo Medical and Dental University (TMDU) have found that the urinary secretion of uromodulin, a kidney-specific protein, can be increased by the hormone vasopressin via certain signaling pathways. Increasing the urinary secretion of uromodulin may protect against urinary tract infections and kidney stones, while the resulting lower uromodulin levels in kidney cells may help to prevent hypertension and chronic kidney disease.
Annu Rev Physiol. 2021 Feb 10;83:477-501. doi: 10.1146/annurev-physiol-031620-092817.ABSTRACTUromodulin, a protein exclusively produced by the kidney, is the most abundant urinary protein in physiological conditions. Already described several decades ago, uromodulin has gained the spotlight in recent years, since the discovery that mutations in its encoding gene UMOD cause a renal Mendelian disease (autosomal dominant tubulointerstitial kidney disease) and that common polymorphisms are associated with multifactorial disorders, such as chronic kidney disease, hypertension, and cardiovascular diseases. Moreover, variations i...