Novel variant fibrinogen γp.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment

CONCLUSION: We demonstrated that fibrinogen N-II, γp.C352R was associated with markedly reduced secretion of variant fibrinogen from CHO cells, that fibrin polymerization of purified plasma fibrinogen was only slightly affected, and that fibrinogen N-II produces hypodysfibrinogenemia in plasma.PMID:34117991 | DOI:10.1007/s12185-021-03174-y

Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Masahiro Yoda Takahiro Kaido Tomu Kamijo Chiaki Taira Yumiko Higuchi Shinpei Arai Nobuo Okumura Source Type: research