Congenital self-healing Langerhans cell histiocytosis presented as ‘purpura-like skin lesions'
At birth, a newborn boy had disseminated purplish patches varying in size from 3 to 5 mm (Fig. 1A). There was no involvement of the mucomembranous surface, lymph nodes, and liver. He was active and stable. A prompt punch biopsy of a representative lesion revealed intensive infiltration of the Langerhans cells that were positive for CD1α and S-100 (Fig. 1B–D). The patient was d iagnosed with congenital Langerhans cell histiocytosis (LCH). Laboratory results including complete blood cell count; blood chemistry results; coagulation; antibodies for HAV, HBV, HCV, rubella, HSV, HIV, and syphilis; and blood cultures were normal.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Wenhui Mo, Jie Zhou, Jianlan Wang, Zhuxiao Ren Tags: Images Source Type: research
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