Introduction: The Inter-relationship Between the Endocrine System and Kidney Health

There is growing appreciation of the complex interaction between various endocrine disorders and kidney disease (Fig. 1).1 Among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), numerous endocrine derangements may ensue and progress, particularly in the uremic milieu (ie, insulin resistance,2 hypogonadotropic hypogonadism,3,4 and secondary hyperparathyroidism5). In turn, the kidneys serve as a major target of the endocrine system, such that alterations in renal structure and function may arise from untreated hormonal derangements (ie, diabetes,6 hypothyroidism,7 and testosterone deficiency8).

Source: Seminars in Nephrology - March 1, 2021 Category: Urology & Nephrology Authors: Connie M. Rhee Source Type: research