Therapies for Neonatal Encephalopathy: Targeting the Latent, Secondary and Tertiary Phases of Evolving Brain Injury

In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia protocols are well established. The current focus is on how to improve outcomes further and the challenge is to find safe and complementary therapies that confer additional protection, regeneration or repair in addition to cooling. Following hypoxia-ischemia, brain injury evolves over three main phases (latent, secondary and tertiary), each with a different brain energy, perfusion, neurochemical and inflammatory milieu.

Source: Seminars in Fetal and Neonatal Medicine - June 12, 2021 Category: Perinatology & Neonatology Authors: Aravanan A. Chakkarapani, Hany Aly, Manon Benders, C. Michael Cotten, Mohamed El-Dib, Pierre Gressens, Henrik Hagberg, Hemmen Sabir, Pia Wintermark, Nicola J. Robertson, Newborn Brain Society Guidelines and Publications Committee Source Type: research