IRE1 α‐mediated monounsaturated fatty acid synthesis drives B cell differentiation and lupus‐like autoimmune disease

ConclusionOur study reveals a molecular link of lipid metabolic dysregulation in lupus pathogenesis, demonstrates that the IRE1 α-XBP-1 pathway controls plasma cell differentiation through SCD1/2-mediated monounsaturated fatty acid synthesis, and provides a rationale for targeting IRE1α and monounsaturated fatty acid synthesis in lupus treatment.

https://onlinelibrary.wiley.com/doi/10.1002/art.41883?af=R

Source: Arthritis and Rheumatology - June 9, 2021 Category: Rheumatology Authors: Yana Zhang, Ming Gui, Yajun Wang, Nikita Mani, Shuvam Chaudhuri, Beixue Gao, Huabin Li, Yashpal S. Kanwar, Sarah A. Lewis, Sabrina N. Dumas, James M. Ntambi, Kezhong Zhang, Deyu Fang Tags: FULL LENGTH Source Type: research