WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the upregulation of IL33 in response to injury

WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of WFDC2 in carcinogenesis is not fully understood. The present study aimed to investigate the role of WFDC2 in gastric carcinogenesis using preneoplastic metaplasia models.

Source: Gastroenterology - June 7, 2021 Category: Gastroenterology Authors: Haengdueng Jeong, Buhyun Lee, Kwang H. Kim, Soo Young Cho, Yejin Cho, Jeongeun Park, Yura Lee, Yeseul Oh, Bo Ram Hwang, Ah-Ra Jang, Jong-Hwan Park, Ji-Ho Park, Sang-Ho Jeong, Daekee Lee, Yong Chan Lee, Kyung-Min Lim, James R. Goldenring, Ki Taek Nam Source Type: research