Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity

Conclusions/interpretationThe major findings of our study were that exercise training altered specific intramuscular lipid intermediates, associated with content-driven increases in mitochondrial respiration but not whole-body insulin sensitivity. This highlights the benefits of exercise training and presents putative target pathways for preventing lipotoxicity in skeletal muscle, which is typically associated with the development of type 2 diabetes.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research