A Method To Label Heparan Sulfate Proteoglycan In The Plasma Membrane Of Mammalian Cells

ID: E-143-2019-0Linked ID: TAB-3417A Method To Label Heparan Sulfate Proteoglycan In The Plasma Membrane Of Mammalian CellsBetty B Tong, Ph.D.tongb@niddk.nih.govPhone: 301-451-7836Inventors: Qi Zhang (NIDDK), Yihong Ye (NIDDK)Lead Inventors: Qi Zhang (NIDDK)Co-Inventors: Yihong Ye (NIDDK)This technology allows a rapid way to detect HSPG on cell surface in live cellsThis is a faster and more cost effective technology which can also be used in live cell imaging to track HSPG-dependent endocytosis of cargo proteins compared to the current practices which use HSPG antibodies to label HSPGThis technology offers a quick method to label the cell boundary-often required in cell biology researchThis technology will be useful to the researchers working on HSPG function in mammalian cellsThis technology will benefit cell biologists in general to quickly label the cell boundary while doing cell imagingThis technology will be useful to researchers working in the field of aging related neurodegenerative studiesInstitute or Center: NIDDKZhang Q, et al A myosin-7B –dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos. PNAS May 19, 2020 117 (20) 10865-10875doi 10.1073/pnas.1918617117EIR ApplicationCollaboration: Collaboration SoughtThe NIDDK is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Method to Label HS...
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