Colorectal Cancer: UVA Health Expert Helps Develop New National Screening Guidelines

(University of Virginia Health System) Most Americans should get screened for colorectal cancer beginning at age 45 instead of age 50, according to new recommendations from the U.S. Preventive Services Task Force, which includes UVA Health's Li Li, MD, PhD, MPH. This recommendation applies to Americans without symptoms who do not have a history of colorectal polyps or a personal or family health history of genetic disorders that increase the risk of colorectal cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.PMID:34536346 | DOI:10.1016/j.chom.2021.08.013
Source: Cell Host and Microbe - Category: Microbiology Authors: Source Type: research
Chest. 2021 Sep 15:S0012-3692(21)03858-7. doi: 10.1016/j.chest.2021.09.003. Online ahead of print.ABSTRACTCystic fibrosis is a progressive monogenetic disorder that causes persistent pulmonary disease, but also affects other organ systems including the digestive tract. Recent advances in treatment and care of CF patients including the use of new and highly effective CFTR modulators, have led to a dramatic increase in survival; young patients with CF can now expect to live to or beyond middle age, where cancer is more frequent. CF patients are now known to face an increased risk of digestive tract cancer-particularly cancer...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research
This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.PMID:34536346 | DOI:10.1016/j.chom.2021.08.013
Source: Cell Host and Microbe - Category: Microbiology Authors: Source Type: research
Anal Chim Acta. 2021 Sep 22;1179:338841. doi: 10.1016/j.aca.2021.338841. Epub 2021 Jul 7.ABSTRACTThe intestinal microbiota is composed of a large number of different bacteria that produce a variety of metabolites. Colorectal cancer, which typically develops from adenomatous polyps, is highly influenced by microbiota. Since a variety of molecular changes may occur as these polyps transform from benign tumor to malignant carcinoma, the ability to study the microbiota-produced metabolites can lead to new discoveries about the development and progression of this cancer. However, to address the complexity of the microbiota-prod...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Source Type: research
This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.PMID:34536346 | DOI:10.1016/j.chom.2021.08.013
Source: Cell Host and Microbe - Category: Microbiology Authors: Source Type: research
CONCLUSION: In this U.S. multicenter tandem colonoscopy RCT, we demonstrate a decrease in adenoma miss rate and SSL miss rate and an increase in first-pass APC with the use of a CADe-system when compared to HDWL colonoscopy.PMID:34530161 | DOI:10.1016/j.cgh.2021.09.009
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusions Our novel approach and algorithm for CRP classification differentiates accurately between benign and premalignant polyps in non-magnified endoscopic images. This is the first algorithm combining three optical modalities (HDWL/BLI/LCI) exploiting the triplet network approach. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Conclusions Outside the scope of academic trials, improvement is needed to increase the reliability of CCE as less than half were considered optimal i. e. complete with adequate bowel cleansing. Most of missed colonic advanced neoplasia were due to incomplete CCE with distal neoplasia location. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Approximately 10% of all colorectal cancer is estimated to be due to an inherited predisposition. Identification of a germline pathogenic variant can aid in treatment, screening, and surveillance and help stratify familial cancer risks based on gene-specific cancer associations. TheAPC gene contributes to a small percentage of hereditary colon cancer, with most pathogenicAPC variants causing familial adenomatous polyposis syndrome. However, one specific variant inAPC called p.I1307K, found in approximately 10% of Ashkenazi Jewish individuals, is associated with a moderate risk for colon cancer, but not polyposis. Heterozyg...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
World J Gastroenterol. 2021 Aug 21;27(31):5272-5287. doi: 10.3748/wjg.v27.i31.5272.ABSTRACTBACKGROUND: The rate of positive tests using fecal immunochemical test (FIT) does not decrease with subsequent campaigns, but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test. A relationship between the fecal hemoglobin concentration (Fhb) and the opportunity to detect a colorectal cancer in subsequent campaign has been shown.AIM: To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening campaign.METHODS...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research
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