Modulating tyrosine sulfation of recombinant antibodies in CHO cell culture by host selection and sodium chlorate supplementation

CONCLUSION: These data suggest that we can control tyrosine sulfation by selecting CHO cell lines based on the expression level of TPST2/SLC35B2 or adding sodium chlorate in upstream production process. This article is protected by copyright. All rights reserved.PMID:34081410 | DOI:10.1002/biot.202100142
Source: Biotechnology Journal - Category: Biotechnology Authors: Source Type: research