The prognosis of epilepsy patients with CACNA1H missense variants: a longitudinal cohort study

The T-type calcium channels Cav3.1, Cav3.2, and Cav3.3 are encoded by CACNA1G, CACNA1H, and CACNA1I, respectively [1]. These are also referred to as low-threshold calcium channels [2]. Among them, Cav3.2 generates low-threshold spikes upon membrane hyperpolarization and directly leads to rebound burst firing of action potentials, which is responsible for the genesis of spike-wave discharges in genetic generalized epilepsy [3]. Rats with genetic absence epilepsy from Strasbourg exhibited an increase in CACNA1H expression in reticular thalamic neurons [4].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research