Beneficial effect of long-chain n-3 polyunsaturated fatty acid supplementation on tuberculosis in mice

Tuberculosis (TB) is an infectious disease characterized by exaggerated and progressive inflammation, lung pathology and tissue damage [1]. Controlling this excessive inflammation may lead to improved TB outcomes [2]. Therefore, anti-inflammatory and inflammation-resolving treatments have been suggested as host-directed therapy (HDT) in TB patients [2]. Dietary polyunsaturated fatty acid (PUFA) consumption alters membrane phospholipid fatty acid (FA) composition of cells that play a role in immune and inflammatory responses in a time- and dose-dependent manner, which affects the pro-inflammatory and inflammation-resolving capacity of these cells [3, 4].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 26, 2021 Category: Biomedical Science Authors: Arista Nienaber, Mumin Ozturk, Robin C Dolman, Lizelle Zandberg, Frank EA Hayford, Frank Brombacher, Renee Blaauw, Cornelius M Smuts, Suraj P Parihar, Linda Malan Source Type: research