A Phenotypic Approach for Personalised Management of Obstructive Sleep Apnoea

AbstractPurpose of ReviewObstructive sleep apnoea (OSA) is a common sleep disorder associated with various symptoms and health consequences. In recent years, it has been increasingly recognised that there are different OSA phenotypes relating to risk factors and pathophysiology as well as clinical expression (symptoms and comorbidity). This review provides a narrative of currently investigated OSA phenotypes relating to disease and treatment which could help move the field towards the future vision of personalised management for OSA.Recent FindingsThere is emerging evidenceOSA phenotypes relating to pathophysiology and clinical expression associate with particular consequences, such as cardiovascular risk. The array of current and emerging OSA therapy options (e.g. continuous positive airway pressure, weight loss, positional therapy, oral appliance therapy, surgery, neuromuscular stimulation, pharmaceuticals) have variations in treatment efficacy and usage across individuals. Identification of treatment response phenotypes could impact treatment selection to maximise downstream benefits of therapy..SummaryA phenotypic approach to matching individuals with OSA to appropriate therapies to mitigate downstream consequences is a framework for personalised management of OSA. Research in this area is ongoing with emergence of potential tools to characterise OSA into anatomical and pathophysiological phenotypes in clinical practice. Enabling technologies and large datasets will aid t...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research