IL-4, IL-17 and CD163 Immunoexpression and IL-6 Gene Polymorphism in Chronic Hepatitis C Patients and Associated Hepatocellular Carcinoma

CONCLUSION: IL-4, IL-17 and CD163 were associated with HCV severity. Their expression in HCC suggests their important role in HCC development. Blocking of these proteins may be a good target to control inflammation in HCV and can hinder progression to cirrhosis then to HCC. On the other hand, IL6-572 promoter gene polymorphism is neither associated with HCV infection nor with HCC development and its progression.<br />.PMID:33906302 | DOI:10.31557/APJCP.2021.22.4.1105

Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Tarek Aboushousha Marine Emad Gina Rizk Khaled Ragab Olfat Hammam Rabab Fouad Noha Said Helal Source Type: research