Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures

Conclusions Novel Hsp90 inhibitors can be developed as antipancreatic cancer agents. Their chemical structures are simpler, and they are likely to exhibit lower side effects than the much more complex inhibitors used as controls.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research

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Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
CONCLUSION: The findings suggest an association between the use of statins and non-selective beta-blockers and reduced pancreatic cancer mortality, and add to the literature supporting the design of randomised clinical trials to evaluate those drugs in the management of pancreatic cancer.PMID:34338111 | DOI:10.1080/0284186X.2021.1953136
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers that lack effective therapeutic options. Here we show that the transcription factor Homeobox C6 (HOXC6) is overexpressed in PDAC and its inhibition blocks PDAC tumor growth and metastasis. By analyzing the HOXC6 shRNA expressing PDAC cells by RNA-sequencing, we identified PPP2R2B and MSK1 as key downstream mediators of HOXC6 function in PDAC. HOXC6 represses PPP2R2B to activate mTOR pathway in PDAC, which in part is necessary for HOXC6-loss induced PDAC inhibition. A...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Neoplasia. 2021 Jul 28;23(9):939-950. doi: 10.1016/j.neo.2021.07.006. Online ahead of print.ABSTRACTAn antibody-drug conjugate (ADC) is a promising therapeutic modality because selective and effective delivery of an anti-cancer drug is achieved by drug-conjugated antibody-targeting cancer antigen. Glypican 1 (GPC1) is highly expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC) and esophageal squamous cell carcinoma (ESCC). Herein, we describe the usefulness of GPC1-targeting ADC. Humanized anti-GPC1 antibody (clone T2) was developed and conjugated with monomethyl auristatin E (MMAE) via maleimid...
Source: Neoplasia - Category: Cancer & Oncology Authors: Source Type: research
Mol Cancer Res. 2021 Jul 30:molcanres.MCR-21-0483-E.2021. doi: 10.1158/1541-7786.MCR-21-0483. Online ahead of print.ABSTRACTPrevious transcriptome studies of human pancreatic ductal adenocarcinoma (PDAC) compare non-cancerous pancreatic intraepithelial neoplasias (PanINs) with late-stage PDAC obtained from different patients, thus have limited ability to discern network dynamics that contribute to the disease progression. We demonstrated previously that the 10-22 cell line, an induced pluripotent stem cell (iPS)-like line reprogrammed from late-stage human PDAC cells, recapitulated the progression from PanNs to PDAC upon t...
Source: Cell Research - Category: Cytology Authors: Source Type: research
AbstractThe extension of a partial pancreatectomy up to total pancreatectomy because of positive neck margin examined at intraoperative frozen section (IFS) analysis is an accepted procedure in modern pancreatic surgery with good accuracy. The goal of this practice is to improve the rate of radical (R0) resection in malignant tumors, mainly pancreatic ductal adenocarcinoma (PDAC), and to completely resect pre-invasive neoplasms such as intraductal papillary mucinous neoplasms (IPMNs). In the setting of IPMNs there is a consensus for pancreatic re-resection when high-grade dysplasia and invasive cancer are present at the ne...
Source: Updates in Surgery - Category: Surgery Source Type: research
In this study, we try to conduct an effective prediction mod...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
CONCLUSION: These results demonstrate that the selected three metabolite panel could be used to stratify patients based on their prognostic outcomes and if independently validated may lead to the development of a urinary prognostic biomarker test for PDAC.GENERAL SIGNIFICANCE: This study highlights the potential of using 1H-nuclear magnetic resonance spectroscopy for the identification of novel metabolites which can prognosticate cancer patients.PMID:34329704 | DOI:10.1016/j.bbagen.2021.129966
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
In conclusion, KLK8 overexpression exerts pro-proliferation and anti-apoptotic functions in pancreatic cancer cells via EGF signaling-dependent activation of PI3K/Akt/mTOR pathway. Upregulated KLK8 in PDAC predicts poor prognosis and may be a potential therapeutic target for PDAC.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
UDP-glucose pyrophosphorylase 2 (UGP2), the enzyme that synthesizes uridine diphosphate (UDP)-glucose, rests at the convergence of multiple metabolic pathways, however, the role of UGP2 in tumor maintenance and cancer metabolism remains unclear. Here, we identify an important role for UGP2 in the maintenance of pancreatic ductal adenocarcinoma (PDAC) growth in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Medical Sciences Biological Sciences Source Type: research
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