Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells

Conclusions. Results of this investigation demonstrated that silencing of HSPB8 mRNA affected the expression of IRS1 gene as well as many other genes encoding tumor growth related proteins. It is possible that the dysregulation of most of the studied genes in glioma cells after silencing of HSPB8 is reflected by a complex of intergenic interactions and that this polyfunctional chaperone is an important factor for the stability of genome function and regulatory mechanisms contributing to the tumorigenesis control.PMID:33885248 | DOI:10.2478/enr-2020-0026

Source: Endocrine Regulations - April 22, 2021 Category: Endocrinology Authors: Oksana S Hnatiuk Dariia O Tsymbal Dmytro O Minchenko Olena O Khita Yulia M Viletska Olha V Rundytska Halyna E Kozynkevych Hanna S Maslak Oleksandr H Minchenko Source Type: research