Dosimetric and clinical outcomes of SpaceOAR in men undergoing external beam radiation therapy for localized prostate cancer: A systematic review

The objective of this systematic review was to evaluate controlled studies on the dosimetric and clinical outcomes of SpaceOAR in men undergoing external beam radiation therapy for localized prostate cancer. Eight studies were included in the review. All of the studies showed SpaceOAR to reduce the radiation dose volume to the rectum over numerous dosimetry levels. Of the four studies that assessed toxicity, one reported SpaceOAR to significantly decrease acute Grade 1 diarrhoea and two reported SpaceOAR to significantly decrease late Grade 1 and Grade ≥2 rectal toxicities. Two studies assessed cumulative incidence of toxicity at 3 years in which one reported SpaceOAR to significantly decrease urinary incontinence and Grade ≥1 and Grade ≥2 rectal toxicities, and the other reported SpaceOAR to significantly decrease Grade 1 diarrhoea and Gra de 2 proctitis. Moreover, one study reported that fewer SpaceOAR patients experienced 10‐point declines in bowel quality of life at 3 years, but another study reported no significant difference in 10‐point declines in bowel quality of life between the SpaceOAR and control groups at 5 years. Wi th the current research available, SpaceOAR may be beneficial to those who did not meet the standard rectal dose‐volume criteria, have higher risk factors of developing rectal toxicities post‐radiation, or wish to decrease the length and costs of radiotherapy by increasing the dose of radiation per fraction.
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Radiation Oncology —Review Article Source Type: research