O07  The increase in erythrocyte mean corpuscular volume by methotrexate is potentiated by hydroxychloroquine and is an early indicator of clinical response in rheumatoid arthritis

Conclusion Our data provides mechanistic insight into the synergistic clinical benefit of concomitant hydroxychloroquine with methotrexate, boosting the rise in erythrocyte MCV which could serve as an early biomarker of treatment response.Disclosure M.R. Shipa: Grants/research support; Versus arthritis.S. Yeoh: Grants/research support; Royal College of Physicians, Rosetrees Trust, NIHR University College London Hospitals Biomedical Research Centre, UCLH Charities.A. Embleton-Thirsk: None.D. Mukerjee: None.M.R. Ehrenstein: Grants/research support; University College London Hospital Biomedical Research Centre.
Source: Rheumatology - Category: Rheumatology Source Type: research