O08  Developing a DNA methylation signature for predicting rheumatoid arthritis using a machine learning pipeline

Conclusion We provide a proof of principle for the application of a B lymphocyte-derived epigenetic signature to enhance prediction of RA in UA patients using stored PBMCs. Further refinement of our pipeline represents a plausible means to expedite the diagnosis in undifferentiated RMDs and could offer path ophysiological insight.Disclosure N. Naamane: None.E. Niemantsverdriet: None.N. Thalayasingam: None.N. Nair: None.A.D. Clark: None.K. Murray: None.B. Hargreaves: None.L.N. Reynard: None.S. Eyre: None.A. Barton: None.A.H.M. van der Helm-van Mil: None.A.G. Pratt: None.
Source: Rheumatology - Category: Rheumatology Source Type: research